The Endocannabinoid System

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The endocannabinoid system is a naturally occurring biological system found within the human body. It is activated by Cannabinoids, causing it to create the powerful effects felt by consuming Cannabis. Endogenous Cannabinoids are naturally occurring Cannabinoids created by the human body, whereas Exogenous Cannabinoids originate from outside of the body. Both categories of these Cannabinoids attach to your Cannabinoid receptors that play a part in the way you feel – physically and mentally.

Endogenous Cannabinoids

There are two main Endogenous Cannabinoids that have been discovered in the human body – Anandamide and 2-AG. These two Cannabinoids can bind and interact with both your CB1 and CB2 receptors. Anandamide and 2-AG are naturally synthesized by your body β€œon demand”. When your body signals that these Cannabinoids are needed, your endocannabinoid system releases them. They are then broken down by your body’s enzymes to process them. Anandamide is typically found in your body, whereas 2-AG is more prominent in the brain. When you consume Cannabis, a wave of Exogenous Cannabinoids enter your body and activate your endocannabinoid system, thus releasing an increased amount of Endogenous Cannabinoids throughout your body.

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The majority of your CB1 receptors are located in your brain and spinal cord. When certain cannabinoids attach to this receptor, they are mainly responsible for emotional effects, appetite stimulation, and memory.


CB2 receptors are more concentrated throughout your body and nervous system. Cannabinoids that bind to this receptor are known to reduce inflammation and pain.

Cannabinoid Receptors

Your brain is filled with receptors that can receive and interpret all kinds of signals created by your body or external molecules. Your Endogenous Cannabinoid system is equipped with two Cannabinoid receptors – CB1 and CB2.

They are responsible for binding and reacting to certain Cannabinoids to create a wide variety of physical, psychological and medicinal benefits for your mind and body. Each Cannabinoid can react to a different Cannabinoid receptor, although some can attach to both CB1 and CB2.

Cannabis Extractions are one way to deliver these compounds. Learn – What are Cannabis Extractions?