The endocannabinoid system is a naturally occurring biological system found within the human body. It is activated by Cannabinoids, causing it to create the powerful effects felt by consuming Cannabis. Endogenous Cannabinoids are naturally occurring Cannabinoids created by the human body, whereas Exogenous Cannabinoids originate from outside of the body. Both categories of these Cannabinoids attach to your Cannabinoid receptors that play a part in the way you feel – physically and mentally.
There are two main Endogenous Cannabinoids that have been discovered in the human body – Anandamide and 2-AG. These two Cannabinoids can bind and interact with both your CB1 and CB2 receptors. Anandamide and 2-AG are naturally synthesized by your body “on demand”. When your body signals that these Cannabinoids are needed, your endocannabinoid system releases them. They are then broken down by your body’s enzymes to process them. Anandamide is typically found in your body, whereas 2-AG is more prominent in the brain. When you consume Cannabis, a wave of Exogenous Cannabinoids enter your body and activate your endocannabinoid system, thus releasing an increased amount of Endogenous Cannabinoids throughout your body.